What Is Type 2 Diabetes?
Unlike people with type 1 diabetes, the bodies of people with type 2 diabetes make insulin. But either their pancreas does not make enough insulin or the body cannot use the insulin well enough. This is called insulin resistance. When there isn’t enough insulin or the insulin is not used as it should be, glucose (sugar) can’t get into the body’s cells. When glucose builds up in the blood instead of going into cells, the body’s cells are not able to function properly.
Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM).
Results showed those with the 677TT and 1298AA mutations were more susceptible to T2DM. Furthermore, these mutations were also found to be risk factors for heart disease and diabetic neuropathys (damage to the nervous system due to high blood sugar).