As latest research comes to hand, we will post links and summaries here for you to access.

Is MTHFR Related to Schizophrenia?

Schizophrenia is a serious and devastating mental illness. Contrary to popular belief, the disease is characterized by paranoid delusions, hallucinations, or disordered thinking and behavior, rather than a “split personality.” While the symptoms can be

Posted On: 4-8-2015 Visibility: Public Read More

MTHFR and Fatty Liver

Fatty Liver Disease isn’t Just an Alcohol Issue It turns out that alcohol isn’t the only culprit when it comes to fatty liver disease (FLD). Elevated homocysteine levels are associated with non-alcoholic fatty liver disease

Posted On: 17-6-2015 Visibility: Public Read More

Folate and Stroke Risk

A stroke can be frightening, debilitating, and sometimes deadly. Strokes are complicated events caused by a variety of contributing factors, including genetics and environment. One potential factor is an elevated level of homocysteine in blood

Posted On: 23-4-2015 Visibility: Public Read More

Do MTHFR Mutations Cause Adult Acute Myeloid Leukemia?

Adult acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow that affects the myeloid type of white blood cells, called myeloblasts. It’s the most common type of acute leukemia

Posted On: 23-4-2015 Visibility: Public Read More

Folate and Neural Tube Risk

Zhang et al (2013) have studied the association between several genes involved in folate metabolism and the risk of developing Neural Tube Defects, of which are the most common and severe congenital malformation worldwide. This

Posted On: 5-9-2014 Visibility: Public Read More

Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet.

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg

Posted On: 23-4-2014 Visibility: Public Read More

Maternal Folic Acid Supplementation & Blood Sugar Imbalances

Huang et al (2014) wished to examine the role maternal nutrition plays in their offspring. Sixty mice were split into 3 groups, and either fed 2mg (the control diet), 5mg (recommended supplemental intake) or 40mg

Posted On: 23-4-2014 Visibility: Public Read More

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. As the

Posted On: 23-4-2014 Visibility: Public Read More

Methylation Rates with Mutated MTHFR and MTR Genes

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. The MTHFR

Posted On: 23-4-2014 Visibility: Public Read More

Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the

Posted On: 23-4-2014 Visibility: Public Read More

MTHFR and MTRR Mutations & Male Infertility

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the

Posted On: 23-4-2014 Visibility: Public Read More

Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant

The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for several disease states such as miscarriage, birth defects and heart disease. While these effects are

Posted On: 23-4-2014 Visibility: Public Read More

Does a MTHFR Mutation Increase Resistance to Malaria?

The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease states. While these are undesirable, the mutation is widespread across many populations worldwide. One of

Posted On: 23-4-2014 Visibility: Public Read More

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed with pre-eclampsia (PE) verse 150 control women. Homocysteine (Hcy) levels were also measured in women

Posted On: 23-4-2014 Visibility: Public Read More

MTHFR and Pre-eclampsia

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first children diagnosed with pre-eclampsia (PE). Homocysteine (Hcy) levels were also measured in women with the

Posted On: 23-4-2014 Visibility: Public Read More

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation within leukocytes.

Posted On: 24-3-2014 Visibility: Public Read More

MTHFR & MTR: Differing effects on Methylation

As both MTR and MTHFR are enzymes involved in the production of methyl groups, Weiner et al (2014) wished to examine the effects of a their gene mutations on levels of DNA methylation. As the

Posted On: 24-3-2014 Visibility: Public Read More

Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population

Methylation and the folate pathway are expected to play an important role in the production of health sperm as it is involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the

Posted On: 24-3-2014 Visibility: Public Read More

MTHFR and Male Fertility

Methylation and the folate pathway are expected to play an important role in the production of healtyh sperm as they are involved in DNA synthesis, repair and methylation. Therefore, Mfady et al (2014) studied the

Posted On: 24-3-2014 Visibility: Public Read More

Increased Resistance to Malaria in Mice with MTHFR Deficiency Suggests a Mechanism for Selection of the MTHFR 677C>T Variant.

The MTHFR C677T mutation is known to results in a deficiency of the enzymes activity and an increased risk for several disease states such as miscarriage, birth defects and heart disease. While these effects are

Posted On: 24-3-2014 Visibility: Public Read More

Malaria Resistance Due to MTHFR

The MTHFR C677T mutation is known to result a decrease in the enzymes function and is associated with several disease states. While these are undesirable, the mutation is widespread across many populations worldwide. One of

Posted On: 24-3-2014 Visibility: Public Read More

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia.

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in 150 nulliparous pregnant women diagnosed with pre-eclampsia (PE) verse 150 control women. Homocysteine (Hcy) levels were also measured in women

Posted On: 24-3-2014 Visibility: Public Read More

MTHFR C677T and A1298C with Preeclampsia

Chedraui et al (2014) examined the prevalence of the MTHFR C677T and A1298C mutations in women pregnant with their first children diagnosed with pre-eclampsia (PE). Homocysteine (Hcy) levels were also measured in women with the

Posted On: 24-3-2014 Visibility: Public Read More

Mechanisms Linking In Utero Stress to Altered Offspring Behaviour.

Development while in the uterus is recognised as a determinate of health in later life and is known as early life programming. Several human studies have shown a link between in utero stressors such as

Posted On: 7-3-2014 Visibility: Public Read More

Stress In Utero + Altered Behaviour in Offspring

Development while in the uterus is recognised as a determinate of health in later life and is known as early life programming. Several human studies have shown a link between in utero stressors such as

Posted On: 7-3-2014 Visibility: Public Read More

Oxidative Stress, T Cell DNA Methylation and Lupus.

Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as UV light, silica, infections and cigarette smoke. However, it is unknown how this oxidative stress

Posted On: 7-3-2014 Visibility: Public Read More

Lupus, Oxidative Stress and Methylation

Lupus development is triggered when genetically predisposed people encounter environmental triggers that cause oxidative stress in the body such as UV light, silica, infections and cigarette smoke. However, it is unknown how this oxidative stress

Posted On: 7-3-2014 Visibility: Public Read More

Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.

African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a young age and to develop tumours with a poor prognosis, with this racial difference largely

Posted On: 7-3-2014 Visibility: Public Read More

Folate, B6 and B12 with Breast Cancer Risk

African American (EA) women are more likely than European American (EA) women to be diagnosed with breast cancer at a young age and to develop tumours with a poor prognosis, with this racial difference largely

Posted On: 7-3-2014 Visibility: Public Read More

Plasma homocysteine levels and genetic polymorphisms in folate metabolism are associated with breast cancer risk in chinese women.

Wu et al (2014) investagted whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy) levels and are associated with breast cancer. Results showed those with elevated Hcy levels had

Posted On: 7-3-2014 Visibility: Public Read More

Breast Cancer, Methylation Genes and Homocysteine

Wu et al (2014) investigated whether genetic mutations of the SHMT, MS, MTRR and CBS genes can affect Homocysteine (Hcy) levels and are associated with breast cancer. Results showed those with elevated Hcy levels had

Posted On: 7-3-2014 Visibility: Public Read More

Are Genes Connected with Homocysteine Metabolism Associated with Bipolar Disorder?

High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients. Therefore, Permoda-Osip et al (2014) wished to understand the correlation between bipolar mood disorder and

Posted On: 7-3-2014 Visibility: Public Read More

Bipolar and CBS Pathway Mutation

High homocysteine levels and mutations in the genes that regulate it have been found in bipolar, depressive and schizophrenic patients. Therefore, Permoda-Osip et al (2014) wished to understand the correlation between bipolar mood disorder and

Posted On: 7-3-2014 Visibility: Public Read More

DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation.

Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated by nutrition early in life. The post natal brain exhibit stimulus-induced methylation changes due to

Posted On: 28-2-2014 Visibility: Public Read More

Methylation and Its Effects on Brain Function

Weng et al (2014) conducted research on young mice to examine how extensively DNA methylation within the brain is regulated by nutrition early in life. The thalamus and hippocampus of malnourished mice were compared to

Posted On: 28-2-2014 Visibility: Public Read More

Intraindividual somatic variations in MTHFR gene polymorphisms in relation to colon cancer.

Rai et al (2014) desired to discover the differences in the prevalence of MTHFR C677T and A1298C prevalence in normal and colon cancer tissue. Therefore, DNA isolated from tumour tissue was examined and compared with

Posted On: 28-2-2014 Visibility: Public Read More

MTHFR and Colon Cancer

Rai et al (2014) wished to discover the differences in MTHFR prevalence in normal and colon cancer tissue. Therefore, DNA isolated from tumour tissue was examined and compared with normal tissue of colon cancer patients.

Posted On: 28-2-2014 Visibility: Public Read More

Methylation of twelve CpGs in human papillomavirus type 16 (HPV16) as an informative biomarker for the triage of women positive for HPV16 infection.

Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve rates of cervical cancer prevention.  The authors Brandsma et al (2014) previously studied 113 samples

Posted On: 28-2-2014 Visibility: Public Read More

Methylation and HPV/ Cervical Cancer

Finding an accurately marker in the follow up of women diagnosed with the human papillomavirus type 16 (HPV16) maybe improve rates of cervical cancer prevention.  The authors Brandsma et al (2014) previously studied 113 samples

Posted On: 28-2-2014 Visibility: Public Read More

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer.

Song et al (2013) examined the association between cancer related genes (named P16, MGMT and HMLH1) with the prevalence of MTHFR in patients with gastric cancer. 322 patients with gastric cancer were examined. Hypermethylation of

Posted On: 28-2-2014 Visibility: Public Read More

Methylation, MTHFR and Gastric Cancer

Song et al (2013) examined the association between several cancer related genes with the prevalence of MTHFR in patients with gastric cancer. Hypermethylation of these cancer related genes was highly evident, which could therefore be

Posted On: 28-2-2014 Visibility: Public Read More

Association between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis.

A meta-analysis on the available evidence concerning the MTHFR C677T polymorphism and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies totaling 1713 cases and 1867 controls were examined, with a significant

Posted On: 28-2-2014 Visibility: Public Read More

MTHFR C677T and Epilepsy

A review on the available evidence concerning MTHFR C677T and susceptibility to epilepsy was studied by Wu et al (2014). Ten studies were examined, with an association between the C677T mutation and epilepsy susceptibility was

Posted On: 28-2-2014 Visibility: Public Read More

Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression

This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age and occurrence of late life depression, and whether these mutations predicted the response to antidepressant

Posted On: 21-2-2014 Visibility: Public Read More

Folate metabolism and Depression

This research by Jamerson et al (2013) wish to discover whether mutations in the folate metabolism pathway predicted the age and occurrence of late life depression, and whether these mutations predicted the response to antidepressant

Posted On: 21-2-2014 Visibility: Public Read More

Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia

Lochman et al (2014) state a possible epigenetic link between MTHFR C677T mutations, high homocysteine and schizophrenia. 192 schizophrenic patients were examined alongside 213 controls, with an increased risk of schizophrenia presentation associated both MTHFR

Posted On: 21-2-2014 Visibility: Public Read More

MTHHFR C677T and Schizophrenia

Lochman et al (2014) state a possible link between MTHFR C677T mutations, high homocysteine and schizophrenia. Through examining a group of schizophrenic patients, an increased risk of schizophrenia presentation was associated with MTHFR 677 CT

Posted On: 21-2-2014 Visibility: Public Read More

Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that are linked with major depressive disorder (MDD). 86 South African patients diagnosed with MDD were studied alongside

Posted On: 21-2-2014 Visibility: Public Read More

Folate, Methylation and Depression

Low folate levels combined with a MTHFR C677T mutation are an important cause of high homocysteine levels that have been found to be linked with major depressive disorder (MDD). Patients diagnosed with MDD were screened

Posted On: 21-2-2014 Visibility: Public Read More

Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey

4709 Turkish patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) over a period of 3 years for the presence of 6 different gene polymorphisms relating to CV health, including Factor 5

Posted On: 21-2-2014 Visibility: Public Read More

Gene Mutations in Cardiovascular Disease

Patients with Cardiovascular Disease (CVD) were screened by Oztuzcu et al (2014) for the presence of 6 different gene polymorphisms relating to CV health, including MTHFR C677T and A1298C mutations. C677T homozygous and heterozygous mutations

Posted On: 21-2-2014 Visibility: Public Read More

Homocysteine Level and Mechanisms of Injury in Parkinson’s Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and L-Dopa Treatment

This review article by Rozycka et al (2014) discusses hyperhomocysteinemia (HHcy) and its effect on Alzheimer’s and Parkinson’s Disease. This is due HHcy being found to have a neurotoxic effect that participates in neuro-degeneration via

Posted On: 21-2-2014 Visibility: Public Read More

High Homocysteine, Parkinson’s and Alzheimer’s Disease

This review article by Rozycka et al (2014) discusses the harmful effects elevated homocysteine (Hcy) levels can play on diseases affecting brain function such as Alzheimer’s and Parkinson’s Disease. This is due to evidence demonstrating

Posted On: 21-2-2014 Visibility: Public Read More

MTHFR A1298C & Oesophageal / Gastric Cancer

This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on the treatment of gastric or oesophageal cancer. These mutations can impact upon cancer outcomes as

Posted On: 11-2-2014 Visibility: Public Read More

A Retrospective Comparative Exploratory Study on two MTHFR Polymorphisms in Esophagogastric Cancer

This study by Blank et al (2014) examined the role of MTHFR C677T & A1298C mutations and their effect on the treatment of gastric or oesophageal cancer due to their influence on folate metabolism and

Posted On: 11-2-2014 Visibility: Public Read More

MTHFR C677T & High Homocysteine in Vegans

High homocysteine in vegetarians and vegans is mainly related to a deficiency in B12. Therefore, methylation in these people can be under-active, but not specifically due to a mutation in an MTHFR gene. This was

Posted On: 11-2-2014 Visibility: Public Read More

C677T Methylenetetrahydrofolate Reductase and Plasma Homocysteine Levels among Thai Vegans and Omnivores

Hyperhomocysteinemia (HHcy) in vegetarians and vegans is mainly related to a deficiency in B12. However, a mutation in the MTHFR C677T gene may also contribute to HHcy. Therefore, blood status of Hcy, B12, folate, B6

Posted On: 11-2-2014 Visibility: Public Read More

MTHFR C677T & Down’s Syndrome

The presence of the MTHFR C677T mutation was studied in a group of mothers with Down’s Syndrome children. Results found the 677TT genotype to be present in 1.8% of the case group, with none of

Posted On: 11-2-2014 Visibility: Public Read More

Prevalence of Methylenetetrahydrofolate reductase 677 C-T Polymorphism Among Mothers of Down Syndrome Children

The presence of the MTHFR C677T polymorphism was studied by Kaur (2013) in 110 mothers of children with Down’s Syndrome against 111 controls in India. Results from this present study had the 677TT genotype to

Posted On: 11-2-2014 Visibility: Public Read More

MTHFR C677T & Coronary Artery Disease

Saffari et al (2013) studied the effect of the MTHFR C677T on high homocysteine levels and therefore coronary artery disease (CAD). Overall the correlation between C677T and CAD was not found to be significant, although

Posted On: 11-2-2014 Visibility: Public Read More

An MTHFR Variant, Plasma Homocysteine Levels and Late-Onset Coronary Artery Disease in Subjects from Southern Iran

Saffari et al (2013) examined the MTHFR C677T mutation and its potential affect on hyperhomocysteinemia (HHcy) and coronary artery disease (CAD). Therefore, the presence of this specific polymorphism and total homocysteine were studied in a

Posted On: 11-2-2014 Visibility: Public Read More

C677T, A1298C, Hypertension & Hypertension in Pregnancy

Yang et al (2014) wished to uncover the role of both the C677T and A1298C mutation in relation to hypertension (H) and hypertension in pregnancy (HIP). Results showed the C677T mutation was associated with both

Posted On: 11-2-2014 Visibility: Public Read More

Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls

A meta-analysis was conducted by Yang et al (2014) to determine the role of MTHFR polymorphisms in hypertension (H) and hypertension in pregnancy (HIP). 114 studies were selected to examine, totaling 15 411 case subjects

Posted On: 11-2-2014 Visibility: Public Read More

Genetic Variants of Homocysteine Metabolism and Multiple Sclerosis: A case-control study

Ineichen et al (2014) studied the effect the MTHFR A1298C variant had on the development of relapsing remitting multiple sclerosis (RRMS) in a German population. 147 Germans with RRMS matched with 147 healthy controls were screened for

Posted On: 10-2-2014 Visibility: Public Read More

Plasminogen Activator Inhibitor-1 4G/5G and the MTHFR 677C/T Polymorphisms and Susceptibility to Polycystic Ovary Syndrome: a meta-analysis.

Lee & Song (2014) conducted a meta-analysis to explore whether plasminogen activator inhibitors-1 (PAI-1) 4G/5G and MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome (PCOS). 9 studies examining PAI-1 with 2384 total subject were employed

Posted On: 10-2-2014 Visibility: Public Read More

Adaptive Developmental Plasticity in Methylenetetrahydrofolate reductase (MTHFR) C677T Polymorphism Limits its Frequency in South Indians

This study was completed in order to examine whether the 677TT polymorphism exhibited adaptive developmental plasticity in 1818 South Indian subjects (895 males + 923 females). The frequency of MTHFR 677T was 9.1% in males + 11.0%

Posted On: 10-2-2014 Visibility: Public Read More

MTHFR/p53 Polymorphisms as Genetic Factors for Cervical Intraepithelial Neoplasia and Cervical Cancer in HPV-infected Mexican Women

A case control study was undertaken to examine the association between common mTHFR C677T/ A1298C polymorphisms and the Arg72ro polymorphisms in the P53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC)

Posted On: 10-2-2014 Visibility: Public Read More

Genetic Polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) gene and Risk of Vitiligo in Han Chinese Populations: a Genotype-phenotype Correlation Study

Evidence has recently revealed that patients with vitiligo are shown to have elevated total Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates HCy metabolism, it is hypothesized by the authors that polymorphisms to

Posted On: 10-2-2014 Visibility: Public Read More

MTHFR C677T Polymorphism and Migraine Risk: A meta-analysis.

This meta-analysis was undertaken to review the current evidence available examining the link between the MTHFR C677T polymorphism and migraine risk across numerous populations. 17 studies were used for this review, with a total of 8903 cases

Posted On: 10-2-2014 Visibility: Public Read More

Methylenetetrahydrofolate reductase C677T and Overall Survival in Pediatric Acute Lymphoblastic Leukemia: a systematic review.

Ojha and Gurney (2014) conducted a meta-analysis to deduce whether the MTHFR C677T mutation was associated with overall survival in paediatric acute lymphoblastic leukaemia. Six studies were employed, totalling 909 paediatric patients with ALL. The current evidence suggests

Posted On: 10-2-2014 Visibility: Public Read More

Association of ACE and MTHFR Genetic Polymorphisms with Type 2 Diabetes Mellitus:Susceptibility and Complications

Settin et al (2014) researched the link between polymorphisms in both ACE and MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM) in an Eygyptian population. 203 patients with T2DM were studied

Posted On: 10-2-2014 Visibility: Public Read More

Is Methylenetetrahydrofolate reductase (MTHFR) Gene A1298C Polymorphism Related with Varicocele Risk?

The MTHFR enzyme is vital for DNA synthesis and methylation, which has a key role during spermatogenesis. Varicocele is one of the main reasons for male infertility, of which the aetiology remains unclear. Therefore, Ucar et al

Posted On: 10-2-2014 Visibility: Public Read More

MTHFR C677T Genotype and Cardiovascular Risk in a General Population Without Mandatory Folic Acid Fortification

Studies have suggested an effect of MTHFR C677T genotype on CVD in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, serum folate B12 and CVD related outcomes in a

Posted On: 10-2-2014 Visibility: Public Read More

Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension

The authors Wang et al (2014) studied the ability of the MTHFR C677T polymorphism to predict hyperhomocysteinemia (HHcy) in Chinese patients with hypertension. Plasma Hcy and the C677T genotype were examined in 1058 Chinese patients with hypertension.

Posted On: 10-2-2014 Visibility: Public Read More

Folate: Metabolism, Genes, Polymorphisms and the Associated Diseases.

This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists the main functional polymorphisms of the MTHFR gene to be C677T, A1298C, with other reported polymorphisms

Posted On: 10-2-2014 Visibility: Public Read More

Polymorphisms of Folate Metabolism-Related Genes and Survival of Patients with Colorectal Cancer in the Korean Population

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. 372 CRC Korean patients (215 men and

Posted On: 10-2-2014 Visibility: Public Read More

Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis

The relationship between Homocysteine (Hcy), MTHFR C677T polymorphism and Cerebral Veno-sinus Thrombosis (CVT) in an Indian population was studied by Bharatkumar et al (2014). 185 patients with CVT were studied against 248 healthy controls. Fasting Hcy was found

Posted On: 10-2-2014 Visibility: Public Read More

Associations Between Methylenetetrahydrofolate reductase Polymorphisms and Hepatocellular Carcinoma Risk in Chinese population.

A meta-analysis conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (HCC) risk in a Chinese Population, as studies linking the two are currently inconclusive. 12 case controlled studies were included

Posted On: 10-2-2014 Visibility: Public Read More

Association of Methylenetetrahydrofolate reductase (A1298C and C677T) Polymorphisms with Retinal Vein Occlusion in Tunisian Patients

The link between MTHFR polymorphisms and the aetiology of retinal vein occlusion (RVO) has not been sufficiently clarified. Therefore, 72 Tunisian patients with RVO compared to a matched group of 140 healthy controls were genotyped for the

Posted On: 10-2-2014 Visibility: Public Read More

Meta-analysis Supports Association of a Functional SNP in the MTHFR Gene with Parkinson’s Disease

A meta-analysis was conducted by Zhu et al (2013) to determine the relationship between the MTHFR C677T polymorphism and the risk of Parkinson’s Disease (PD) in general populations. Case controlled samples from European and Asian populations were

Posted On: 10-2-2014 Visibility: Public Read More

Folic Acid SNP’s Associated with Methotrexate Significant Adverse Events in United States Veterans with Rheumatoid Arthritis

319 patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis were genotyped for several SNP’s involved in the folic acid pathway (folylpoly-gamma-glutamate synthetase (FPGS), gamma-glutamyl hydrolase (GGH),MTHFR A1298C + C677T)) to establish their association with MTX + significant adverse

Posted On: 10-2-2014 Visibility: Public Read More

MTHFR & Multiple Sclerosis

The MTHFR enzyme plays a very important role in ensuring the nervous system stays healthy, by governing the coating of nerves in protective layer which allows them to function strongly. In this study, Ineichen et

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T & Polycystic Ovarian Syndrome (PCOS)

Lee & Song (2014) conducted research to explore whether MTHFR C677T polymorphisms are associated with susceptibility to Polycystic Ovarian Syndrome (PCOS). Analysis of the results showed no correlation between PCOS and the C677T allele. Article

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T Genetic Adaptability

The body has the ability to change its genetics in response to changes in the environment. Therefore, this study was completed by Naushad et al (2014) to examine the 677TT polymorphism and its adaptive ability.

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR A1298C & Cervical Dysplasia/ Cancer

A case control study was undertaken to examine the association between common MTHFR C677T/ A1298C polymorphisms and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in women with the HPV virus.

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR & Vitiligo

Patients with vitiligo are shown to have elevated Homocysteine (Hcy). As MTHFR is one of the main enzymes that regulates Hcy metabolism, it is hypothesized by authors Chen et al (2014) that mutations to these

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T & Migraine Risk

This research was undertaken to review the link between the MTHFR C677T and migraine risk. Collective results showed the 677T allele was significantly associated with an increased risk for total migraine in Asian populations. Article

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T & Leukaemia Survival

Ojha and Gurney (2014) studied whether MTHFR C677T was associated with overall survival in childhood leukaemia. The current evidence suggests that individuals with at least one T allele in the C677T gene code may have

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR & Type 2 Diabetes Mellitus

Settin et al (2014) researched the link between mutations in the MTHFR genes and the susceptibility for and complications of Type 2 Diabetes Mellitus (T2DM). Results showed those with the 677TT and 1298AA mutations were

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR A1298C & Male Infertility

Varicocele is the presence of widened veins, like varicose veins on the outside of the testicle and is one of the main reasons for male infertility. The MTHFR enzyme is also vital for production of

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T + Cardiovascular Risk

Studies have suggested MTHFR C677T plays a role in the development of Cardiovascular Disease (CVD) in populations with low dietary folate intake. Therefore, the authors aimed to examine the association between MTHFR, folate and CVD

Posted On: 4-2-2014 Visibility: Public Read More

Predicting High Homocysteine with MTHFR C677T

The authors Wang et al (2014) studied the ability of MTHFR C677T  to predict high homocysteine in Chinese patients with hypertension. Overall, the 677TT genotype was consistently associated with higher homocysteine across the group, with

Posted On: 4-2-2014 Visibility: Public Read More

Review: Folate Metabolism, Genes + Polymorphisms

This review article by Nazki et al (2014) examined the evidence currently available on folate, methylation and genetic polymorphisms. It lists the main functional polymorphisms of the MTHFR gene to be C677T and A1298C. In

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR C677T + Colorectal Cancer

Jang et al (2014) studied survival rates of Colorectal Cancer (CRC) in a Korean population in relation to 3 genetic polymorphisms, of which MTHFR mutations C677T and A1298C were included. The C677T mutation was the

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MTHFR C677T, High Homocysteine + Blood Clot Risk

The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al (2014). Homocysteine was higher in patients with cerebral blood clotting, representing a 4.54 fold increased

Posted On: 4-2-2014 Visibility: Public Read More

MTHFR Polymorphisms & Liver Cancer

Research conducted by Qi et al (2014) examined the influence of MTHFR polymorphisms on Hepatocellular Carcinoma (Liver Cancer) risk in a Chinese Population. Results showed that both the C677T and A1298C mutation were significantly associated

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MTHFR A1298C + C677T Associated with Blood Clotting

The true cause of blood clotting of the retina’s vein was examined in this study be Mrad et al (2014). Results showed the A1298C polymorphism to be significantly associated with clotting of the retinal vein.

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MTHFR C677T & Parkinson’s Disease Risk

Zhu et al (2013) examined evidence to uncover an association between MTHFR C677T  and the risk of PD, with overall risk found to be increased in European populations compared with Asian populations. Article Here  

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MTHFR A1298C, Methotrexate & Adverse Events

Research conducted by Davis et al (2014) found patients prescribed Methotrexate (MTX) for diagnosed rheumatoid arthritis had a 3.05 increased risk of adverse events in the presence of the A1298C mutation. Article Here

Posted On: 3-2-2014 Visibility: Public Read More